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Protein Binding
- PPB
- Full plasma
- HSA
- RSA
- AGP / AAG
Brain Tissue Binding
Brain-to-Plasma Distribution
Microsomal Binding
Intestinal Absorption
Trusted ADMET
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News

22/03/20173B Pharmaceuticals and Sovicell introduce a novel service offering for plasma protein binding analysis

Products

Ready-to-use assay systems for DMPK and ADMET studies

TRANSILXL RSA Binding kit

A fast high throughput assay for measuring the dissociation constant of drugs from rat serum albumin (RSA).

The dissociation constant is used in screening to rapidly predict plasma binding or to model plasma binding under various physiological and disease states using our spreadsheet software or Simcyp™.

Features
  • Ready-to-use 96-well microtiter plates carrying TRANSIL beads with albumin immobilized in random orientation to expose all binding sites. The assay is designed to conveniently measure albumin binding of drugs.
  • Includes spreadsheet, facilitating manipulation of statistical parameters and calculation of final results.
  • Designed for automated liquid handlers or manual pipetting.
Benefits
  • TRANSIL beads are integrated into 96-well microtiter plates to enable easy handling.
  • One plate can be used to measure HSA binding of up to 12 compounds.
  • Only 12 minutes assay incubation time.
  • Rapid compound quantification due to immobilized albumin (e.g. injection via RapidFire™).
  • Highly reproducible results and robust correlation with conventional dialysis technique.
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Sovicell GMBH, Deutscher Platz 5b, 04103 Leipzig, Germany    t: +49 341 520 44 0   f: +49 341 520 44 12